P2Y12 expression and function in alternatively activated human microglia
نویسندگان
چکیده
منابع مشابه
P2Y12 expression and function in alternatively activated human microglia
OBJECTIVE To investigate and measure the functional significance of altered P2Y12 expression in the context of human microglia activation. METHODS We performed in vitro and in situ experiments to measure how P2Y12 expression can influence disease-relevant functional properties of classically activated (M1) and alternatively activated (M2) human microglia in the inflamed brain. RESULTS We de...
متن کاملP2Y12 expression and function in alternatively activated human microglia
In the article " P2Y12 expression and function in alternatively activated human microglia " by C.S. Moore et al. (Neurology ® Neuroimmunology & Neuroinflammation 2015;2:e80), there is an error in figure 6, panel C, first image. The image should have been titled CD163. The editorial staff regrets the error.
متن کاملDifferential Kv1.3, KCa3.1, and Kir2.1 expression in “classically” and “alternatively” activated microglia
Microglia are highly plastic cells that can assume different phenotypes in response to microenvironmental signals. Lipopolysaccharide (LPS) and interferon-γ (IFN-γ) promote differentiation into classically activated M1-like microglia, which produce high levels of pro-inflammatory cytokines and nitric oxide and are thought to contribute to neurological damage in ischemic stroke and Alzheimer's d...
متن کاملP2Y12 receptor upregulation in activated microglia is a gateway of p38 signaling and neuropathic pain.
Microglia in the spinal cord may play an important role in the development and maintenance of neuropathic pain. A metabotropic ATP receptor, P2Y(12), has been shown to be expressed in spinal microglia constitutively and be involved in chemotaxis. Activation of p38 mitogen-activated protein kinase (MAPK) occurs in spinal microglia after nerve injury and may be related to the production of cytoki...
متن کاملAlternatively activated and immunoregulatory monocytes in human filarial infections.
BACKGROUND Monocytes/macrophages from filaria-infected animals exhibit an alternatively activated phenotype; however, very little is known about the alternative activation phenotype of monocytes in human filarial infection. METHODS To elucidate the activation and cytokine profile of monocytes in human filarial infection, we examined the expression patterns of genes encoding arginase, nitric o...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Neurology - Neuroimmunology Neuroinflammation
سال: 2015
ISSN: 2332-7812
DOI: 10.1212/nxi.0000000000000080